Sermorelin with GHRP 2 and 6 are no longer available, now what?

For many HRT patients Sermorelin in combination with GHRP2 and GHRP6 was a peptide that offered improved sleep, more energy, fat loss, and increased muscle gain. Growth hormone secretagogues increase HGH through release of IGF-1 or insulin-like growth factor in the liver. AAI has all the information you need on the improved formulas they are being replaced with.

What is Sermorelin? 

Sermorelin mimics GHRH, or growth hormone releasing hormone. It is made up of 29 amino acids. This hormone increases the body’s natural growth hormone secretion.  Sermorelin is now thought to be more outdated, however still offers an alternative to patients who are sensitive to similar compounds.

What is CJC? 

It’s primary function acts on GHRH receptors much like Sermorelin does.  CJC is made up of 30 amino acids.  The main difference between the two is that CJC’s therapeutic window is greater, working on the receptors for 30 minutes instead of 8-12 minutes like that of Sermorelin.  CJC also stimulates pituitary gene transcription, which basically helps the body to preserve the growth hormone reserve gained through treatment.

What is Ipamorelin?

Think of Ipamorelin as a growth hormone releasing peptide much like GHRP2/GHRP6 that mimics Ghrelin targeting a specific GH pulse that not only increases growth hormone release but also suppresses somatostatin. This process works best synergistically with use of Sermorelin or CJC or can be used on it’s own.

Ipamorelin is considered the best GHRP, in that it doesn’t cause spikes in other important hormone levels and also does not increase hunger after injecting. This is particularly important for patients looking to shred some extra pounds and greatly increases the positive clinical outcomes they receive. 

Which benefits are typically seen with secretagogues and what is the timeline for the benefits it offers?

• Increase bone density/calcium retention
• Increase muscle mass/decrease in body fat 
• Improvement in Cardiovascular health
• Repairs old injuries/Regenerates nerve tissue
• Improved skin appearance and elasticity
• Increased sex drive
• Improved energy and sleep patterns
• Enhances mental performance and cognitive function
• Strengthens the immune system